ABSTRACT
Abstract Introduction Advanced Glycation End-Products (AGEs) are a diverse group of highly reactive molecules that play a vital role in the development of neurodegenerative disorders, such as Parkinson's Disease (PD), leading to a decline in functional and cognitive capacity. The objective of this study was to assess the intake and quantification of AGEs in individuals with PD and to correlate them with their functional and cognitive abilities. Methods This was a cross-sectional study involving 20 PD patients and 20 non-PD individuals as the Control group (C). The autofluorescence reader was used to evaluate skin AGEs, while food recall was used to quantify AGEs consumed for three different days. The Montreal Cognitive Assessment, Short Physical Performance Battery, and handgrip tests were used. PD patients demonstrated greater impairment in functional capacity compared to the control group. Results Dominant Handgrip (p = 0.02) and motor performance, in the sit and stand test (p = 0.01) and Short Physical Performance Battery (SPPB) (p = 0.01) were inferior in PD patients than the control group. Although PD patients tended to consume less AGEs than the control group, AGE intake was negatively correlated with handgrip strength in individuals with PD (r = -0.59; p < 0.05). Conclusion PD patients had lower strength and functional capacity, suggesting that the effects of AGEs might be exacerbated during chronic diseases like Parkinson's.
ABSTRACT
ABSTRACT Objective: To evaluate the association between bone mineral density (BMD) and body composition in healthy older adults at different skeletal sites. Methods: We analyzed 87 medical records and BMD along with the body composition of men ranging from 60 to 87 years of age (mean: 68.5, standard deviation: 6.5). Inclusion criteria were normal BMD values (T-score greater than or equal to -1.0) and body mass index within normal or overweight range (18.5 to 29.5 kg/m2). Body composition was evaluated using bone densitometry with dual-energy X-ray absorptiometry (DEXA) in a LUNAR-DPX apparatus. Results: Greater lean mass, fat mass, and soft tissue was associated with better BMD values in older adults, and higher age was associated with poorer BMD. Conclusion: Body composition (lean and fat masses and soft tissue) in older men is positively associated with BMD at all body sites (arms, legs, and trunk). Level of Evidence II; Prognostic studies - Investigating the effect of a patient characteristic on the outcome of disease.
RESUMO Objetivo: Avaliar a associação entre a DMO e a composição corporal em idosos hígidos em diferentes sítios esqueléticos. Métodos: Foram analisados 87 prontuários e exames de DMO com composição corporal de idosos do sexo masculino com média de idade de 68,5 (6,5) variando de 60 a 87 anos. Os critérios de inclusão foram valores de DMO dentro do normal (T-score maior ou igual a -1,0); IMC dentro dos valores normais ou sobrepeso (18,5 a 29,5 kg/m2). A composição corporal foi avaliada por meio de densitometria óssea por dupla emissão de raios-X (DEXA) em aparelho LUNAR-DPX. Resultados: Quanto maior as massas magra e gorda e os tecidos moles, melhor os valores da DMO dos idosos e quanto maior a idade, pior a qualidade da DMO. Conclusão: A composição corporal (massas magra e gorda e tecidos moles) de homens idosos associa-se positivamente na DMO em todos os locais do corpo (membros superiores, inferiores e tronco). Nível do Evidênci II; Estudos prognósticos - Investigação do efeito de caractetísticas de um paciente sobre o desfecho da doença.